Thomas P. Flagg, Ph.D., Instructor

Department of Cell Biology and Physiology
Washington University School of Medicine
660 S. Euclid Ave., Box 8228
St. Louis, MO 63110
Ph: (314)362-6629
E-mail: tflagg at cellbiology dot wustl dot edu

EDUCATION:

Ph.D., University of Maryland, Baltimore, MD, 21201
July 1996 – May 2001
Major: Physiology; Mentor: Paul A. Welling, M.D.
Thesis Title: Identification and Characterization of a COOH-terminal Determinant of Kir1.1a Channel Function

M.S., University of Maryland, Baltimore, MD 21201
August 1994 – May, 1996
Major: Physiology

B.S., Stevens Institute of Technology, Hoboken, NJ, 07030
August 1989 – May 1993
Major: Chemical Biology; Minor: History

PROFESSIONAL EXPERIENCE:

1994-1995 Laboratory Scientist I, Maryland Department of Health and Mental Hygiene.

1995-2001 Graduate Research Assistant, Department of Physiology, University of Maryland, Baltimore.

2001-2004 Postdoctoral Fellow, Department of Cell Biology and Physiology, Washington University, St. Louis, MO.

2004-present Instructor, Department of Cell Biology and Physiology, Washington University, St. Louis, MO.

RESEARCH PUBLICATIONS:

Flagg, T.P., M. Tate, J. Merot, and P.A. Welling. A Mutation Linked with Bartter’s Syndrome Locks Kir1.1a (ROMK1) Channels in a Closed State. J Gen Physiol 114: 685-700, 1999. [Abstract]

Gregerson, K.A., T.P. Flagg, T.J. O'Neill, M. Anderson, O. Lauring, J.S. Horel, P.A. Welling. Identification of G protein-coupled, Inward Rectifier Potassium Channel Gene Products from the Rat Anterior Pituitary Gland. Endocrinology 142: 2820-32, 2001. [Abstract]

Luker G.D., T.P. Flagg, Q. Sha, K.E. Luker, C.M. Pica, C.G. Nichols, D. Piwnica-Worms. MDR1 P-glycoprotein Reduces Influx of Substrates Without Affecting Membrane Potential.
J Biol Chem. 276: 49053-60, 2001. [Abstract]

Koster, J.C., A. Knopp, T.P. Flagg, K.P. Markova, Q. Sha, D. Enkvetchakul, T. Betsuyaku, K.A.Yamada, C.G. Nichols. Tolerance for ATP-insensitive KATP Channels in Transgenic Mice. Circ Res 89: 1022-9, 2001. [Abstract]

Koster J.C., M.S. Remedi, T.P. Flagg, J.D. Johnson, K.P. Markova, B.A. Marshall, and C.G. Nichols. Hyperinsulinism Induced by Targeted Suppression of ???cell KATP Channels.
PNAS 99:16992-7, 2002. [Abstract]

Flagg, T.P., D. Yoo, C.M. Sciortino, M. Tate, M.F. Romero and P.A. Welling. Molecular Mechanism of a COOH-terminal Gating Determinant in the ROMK Channel Revealed by a Bartter’s Disease Mutation. J Physiol 544: 351-362, 2002. [Abstract]

Flagg, T.P., F. Charpentier, J. Manning-Fox, M.S. Remedi, D. Enkvetchakul, A. Lopatin, J.C. Koster, and C.G. Nichols. Remodeling Of Excitation-Contraction Coupling In Transgenic Mice Expressing ATP-Insensitive Sarcolemmal KATP. Am J Physiol Heart Circ Physiol 286: H1361-H1369, 2004. [Abstract]

Yoo, D, T.P. Flagg, O. Olsen, V. Raghuram, J.K. Foskett, and P.A. Welling. Assembly and Trafficking of a Multiprotein ROMK (Kir1.1) Channel Complex by PDZ Interactions. J Biol Chem 279: 6863-6873, 2004. [Abstract]

Flagg, T.P. and C.G. Nichols. Sarcolemmal KATP Channels in the Heart: Molecular Mechanisms Brought to Light, but Physiologic Consequences Still in the Dark. J Cardiovasc Electrophys 12: 1195-1198, 2001. [Abstract]

Flagg, T.P. and C.G. Nichols. Sarcolemmal KATP channels: what do we really know? J Mol Cell Cardiol. 39:61-70, 2005. [Abstract]

Flagg, T.P., M.S. Remedi, R. Masia, J. Gomes, M. McLerie, A.N. Lopatin and C. G. Nichols. Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal KATP. J Mol Cell Cardiol. In press, 2005 [Abstract]

HONORS AND AWARDS:

1989-1993, Stevens Academic Fellowship

1995-1997, NIH Predoctoral Training Grant, Membrane Program

1999, 3rd Place, Graduate Student Poster Presentation, Biology of Potassium Channels, From Molecules To Disease. American Physiological Society, Snowmass Village, CO.

1999, 2nd Place, Oral Presentation, Biochemistry Section, Graduate Student Research Day, Univ. of Maryland at Baltimore, Baltimore, MD.

2001-2002, Keck Fellowship

2001-2004, NIH Postdoctoral Training Grant, Cardiovascular Training Grant