Maria Remedi

Department of Cell Biology and Physiology
Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8228
St. Louis, MO

Telephone: Work: 314-362-6629
Fax: 314-362-7463
E-mail: mremedi at cellbiology dot wustl dot edu

Education

National University of Cordoba, Argentina
M.S. 1987 Biochemistry

National University of Cordoba, Argentina
M.S. 1989 Pharmacology

National University of Cordoba, Argentina
Ph.D. 1999 Biochemistry and Molecular Biology

Scientific Education and Employment:

1989-1995 Research Assistant, Department of Biochemistry, School of Medicine, National University of Cordoba, Argentina.
1995-1999 Ph.D. Student, Department of Biochemistry, School of Medicine. National University of Cordoba. Argentina.
1995-1999 Research Assistant, Department of Biochemistry, School of Medicine. National University of Cordoba. Argentina.
1995-1997 Fellowship from Science and Technology Council of National University of Cordoba, First level. Cordoba, Argentina.
1997-1999 Fellowship from Science and Technology Council of National University of Cordoba, Second level, advanced. Cordoba, Argentina.
1999-2001 Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, School of Medicine, National University of Cordoba. Cordoba, Argentina.
2001-2003 Research Associate, Department of Cell Biology and Physiology, Washington University School of Medicine. USA.
2003-2005 Postdoctoral fellow. American Diabetes Association and Takeda Pharmaceuticals Mentor-based Minority postdoctoral fellowship.
2005- Research Associate, Department of Cell Biology and Physiology, Washington University School of Medicine. USA.

Honors and Awards:

1994-2000 Incentive Program, Ministry of Culture and Education of Argentina
1995-1998 Travel Grant from Science and Technology Council of National University of Cordoba, Argentina
1997-1999 Research Fellowship, Science and Technology Council of National University of Cordoba, First Level, Argentina.
1997-1999 Science and Technology Council of National University of Cordoba, Research fellowship, Advanced Level Argentina,
1998 Brazilian-Argentinean Center of Biotechnology, Fellowship for an International Course, Brazil
1999 Brazilian Argentinean Center of Biotechnology, Travel Grant, Brazil.
2000 Science and Technology Council of National University of Cordoba, Travel Grant, Argentina.
2001 Special research seminar at Washington University, Department of Microbiology. Host: Stephen Beverly.
2003 -2005 American Diabetes Association and Takeda Pharmaceuticals Mentor-based Minority Postdoctoral Fellowship Award

Teaching Responsibilities

1989-1999 Instructor of Biochemistry, Dept of Biochemistry, National University of Cordoba, School of Medicine,. Cordoba, Argentina.

1999-2001 Instructor of Biochemistry, Department of Biochemistry and Molecular Biology, National University of Cordoba, School of Medicine. Cordoba, Argentina.

Memberships

American Diabetes Association (2002- ); Biophysical Society (2003- ); Argentine Society of Biochemistry and Molecular Biology (1992- ).

PUBLICATIONS
Peer-reviewed articles:

1. Scaraffía P.Y., Remedi M.S., Maldonado C., Aoki A. and Gerez de Burgos N.M. (1997). Enzymatic and ultraestructural changes in thoracic muscles of triatomine insects during the last stage of metamorphosis.. Comp. 116 A : 173-179.Biochem. Physiol.
2. Ramos A., Remedi M. S., Sanchez C., Bonacci G., Vides M. and Chiabrando G. . (1997). Inhibitory effects of human?2- macroglobulin on Trypanosoma cruzi epimastigote proteinasesActa Tropica 68: 327-337. [abstract]
3. Remedi, M.S., G. Civallero, R. Dodelson de Kremer y N. Gerez de Burgos. (2000). Modificaciones selectivas enlas concentraciones de aminoácidos y cambios en la actividad de proteinasas en Trypanosoma cruzi. Medicina Vol 60 (Supl. III): 101.
4. Alonso G., Pereira C., Remedi M.S., Pavetto M.C., Cochella L., Ivaldi M.S., Gerez de Burgos N.M., Torres H. and Flawiá M. (2001). Arginine kinase of the flagellate protozoa Trypanosoma cruzi. Regulation of its expression and catalytic activity. FEBS Letters. 498: 22-25.[abstract]
5. Ramos A., Duschak V, Gerez de Burgos NM., Barboza M., Remedi M.S., Vides, M., Chiabrando, G. (2002). Trypanosoma cruzi: cruzipain and membrane-bound cysteyne proteinase isoform(s) interact with human Alpha 2-Macroglobulin and Pregnancy Zone Protein. Exp Parasitol. 100: 121-30.[abstract]
6. ** Koster J.C., **Remedi M.S Flagg T.P., Johnson J.D., Markova K.P., Marshall B.A., Nichols C.G. (2002) Hyperinsulinism induced by targeted suppression of beta cell KATP channels. Proc Natl Acad Sci U S A. 99:16992-16997. ** Equal contribution. [abstract]
7. ** Koster J.C., **Remedi M.S., Qiu H., Nichols C.G., Hruz P.W. HIV protease inhibitors acutely impair glucose-stimulated insulin release. (2003) Diabetes. 52:1695-1700. ** Equal contribution. [abstract]
8. Flagg T.P, Charpentier F, Manning-Fox J, Remedi MS, Enkvetchakul D, Lopatin A, Koster J, Nichols C. Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels. (2004) Am J Physiol Heart Circ Physiol. 286:H1361-1369. [abstract]
9. Kwon G., Marshall C.A., Pappan K.L., Remedi M.S., McDaniel M.L. Signaling Elements Involved in the Metabolic Regulation of mTOR by Nutrients, Incretins, and Growth Factors in Islets. (2004) Diabetes. vol 53 Suppl 3:S225-32. Review. [abstract]
10. Remedi, M.S., J.C. Koster, K. Markova, S. Seino, T. Miki, B. Patton, M. McDaniel and C.G. Nichols (2004). Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels. Diabetes 53, 3159-3167. [abstract]
11. Koster, J.C., Remedi M.S., Dao C. and Nichols C.G. (2005) ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: Implications for pharmacogenomic therapy. Diabetes 54, 2645–2654. [abstract]
12. Flagg, T.P., Remedi M.S., Masia R., Gomes J.., McLerie M., Lopatin A.N. and Nichols C.G. (2005) Transgenic overexpression of SUR1 in the Heart suppresses sarcolemmal KATP. J. Mol. Cell. Cardiol. [abstract]
13. Remedi, M.S., Koster, J.C., Patton B. and Nichols C.G. (2005). KATP-signaling in glucokinase-deficient diabetes (In press 7/05).

Book Chapters:

14. Scaraffía, P., Remedi, M.S., Maldonado, C., Aoki, A. and Gerez de Burgos, N.M. (1999). Thoracic muscles of triatomine insects: biochemical adaptations for flight activity”. In: Atlas of Chagas Disease vectors in the Americas Vol III Capter 25 pp 1105-1113 (Carcavallo, R., Galindez Girón, I., Jurberg, J. and Lent, H. Eds) Fiocruz editorial, New York.