Hai Xia Zhang
Postdoctoral Research Associate
Department of Cell Biology and Physiology
Washington University School of Medicine
660 South Euclid Ave., Campus Box 8228, St. Louis, MO 63110
Tel: 314-362-0349 (work)
Fax: 314-362-7463 E-mail: hzhang23@wustl.edu
EDUCATION:
Sept. 2001 - July 2004, Ph.D.
Major: Neuropharmacology
Chinese Academy of Medical Sciences & Peking Union Medical College,
Beijing, China
Sept. 1998 - July 2001, M.S.
Major: Cardiovascular Pharmacology
Weifang Medical College, Weifang, China
Sept.1993 - July 1998, M.D.
Major: Clinical Medicine
Weifang Medical College, Weifang, China
PROFESSIONAL EXPERIENCE:
2009-present, Postdoctoral Fellow
Department of Cell Biology and Physiology, Washington University in St. Louis
2005-2008, Postdoctoral Fellow
Department of Neurology, Washington University in St. Louis
1998-2001, Teaching Assistant
Weifang Medical College, Weifang, China
PROFESSIONAL MEMBERSHIPS:
2006-present Society for Neuroscience
2001-2005 Chinese Pharmacologic Society
PUBLICATIONS:
Zhang H, Flagg TP, and Nichols CG. Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale! (review) J Mol Cell Cardiol. 2009 Jul 14. [Epub ahead of print]
Zhang HX, Lyons-Warren A, and Thio LL. The glycine transport inhibitor sarcosine is an inhibitory glycine receptor agonist. Neuropharmacology. 2009 Jul 18. [Epub ahead of print]
Zhang HX, Hyrc K, and Thio LL. The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. J Physiol. 2009 Jul 1; 587(Pt 13):3207-20.
Xu L, Rensing N, Yang XF, Zhang HX, Thio LL, Rothman SM, Weisenfeld AE, Wong M, and Yamada KA. Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J Clin Invest. 2008 Jan; 118(1):272-80.
Zhang HX and Thio LL. Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons. J Neurophysiol. 2007 Dec; 98(6):3666-76.
Thio LL and Zhang HX. Modulation of inhibitory glycine receptors in cultured embryonic mouse hippocampal neurons by Zinc, Thiol containing redox agents and carnosine. Neuroscience. 2006; 139(4):1315-27.
Yu HB, Li ZB, Zhang HX, and Wang XL. Role of potassium channels in Abeta (1-40)-activated apoptotic pathway in cultured cortical neurons. J Neurosci Res. 2006; 15; 84(7):1475-84.
Zhang HX, Li ZB, and Wang XL. mRNA expression of voltage-dependant potassium channels in the brain of rats after middle cerebral artery occlusion. Acta Pharmaceutica Sinica. 2006; 41(4):328-32. Chinese.
Li ZB, Zhang HX, Li LL, and Wang XL. Enhanced expressions of arachidonic acid-sensitive tandem-pore domain potassium channels in rat experimental acute cerebral ischemia. Biochem Biophys Res Commun. 2005; 25; 327(4): 1163-9.
Zhang HX, Zhang W, Jin HW, and Wang XL. Galantamine blocks cloned Kv2.1, but not Kv1.5 potassium channels. Brain Res Mol Brain Res. 2004; 24; 131(1-2): 136-40.
Zhang HW, Zhang YZ, Zhang HX, Chen XG, Wang XL and Yu CJ. Electrophysiological functions of adult rat marrow stromal cells before and after differentiating into neurons induced by astrocytes. Chinese Journal of Neuomedicine. 2004; 3(5) 324-326. Chinese.
Zhang HX and Wang XL. Molecular components and mechanism of oxygen-sensitive potassium channels (review). Chinese Pharmacological Bulletin. 2004; 20(8): 841-4. Chinese.
Zhang W, Jin HW, Zhang HX, Xu SF, Yu HB, and Wang XL. Effect of 17beta-estradiol on Kv2.1 current and delayed rectifier potassium current in cultured rat hippocampal neurons. Acta Pharmaceutica Sinica. 2004; 39(9): 686-90. Chinese.
MEETING PRESENTATION AND ABSTRACTS:
Glukhov A, Flagg TP, Zhang HX, Fedorov VV, Efimov IR, Nichols CG. Regional heterogeneity of KATP channel opener effects in the intact murine heart reflects distinct atrial and ventricular KATP structure. Keystone Symposia on Molecular and Cellular Biology, Common Mechanisms in Arrhythmias and Heart Failure. Keystone, Colorado, 2009.
Zhang H and Thio L. Sarcosine, an Antischizophrenic Agent and Glycine Transporter I Inhibitor, Is an Inhibitory Glycine Receptor Agonist and N-Methyl-D-Aspartate Receptor Co-agonist. 38th Annual Meeting of Society for Neuroscience, Washington, DC. 2008. Online Society for Neuroscience Meeting Planner Program No.55.13, 2008.
Zhang H. and Thio L. Leptin inhibits neuronal bursting in cultured hippocampal neurons. 61st Annual Meeting of American Epilepsy Society. Philadelphia, Pennsylvania, 2007. Epilepsia 48 (S6): 254, 2007.
Zhang H. and Thio L. Cross-talk between glycine receptors and GABA receptors in cultured hippocampal neurons. 37th Annual Meeting of Society for Neuroscience, San Diego, California 2007. Online Society for Neuroscience Meeting Planner Program No. 874.17, 2007.
Zhang HX and Thio LL. Zinc potentiates strychnine sensitive glycine receptor mediated inhibition of bursting in cultured hippocampal neurons. 60th Annual Meeting of American Epilepsy Society, San Diego, California 2006. Epilepsia 47 (S4): 241, 2006.
Zhang HX and Thio LL. Zinc potentiates inhibitory glycine receptor mediated tonic inhibition of cultured hippocampal neurons. 36th Annual Meeting of Society for Neuroscience, Atlanta, Georgia, 2006. Online Society for Neuroscience Meeting Planner Program No. 233.13, 2006.
Wang XL, Yu HB, Zhang HX, Li ZB, and Wang L. Role of potassium channels in Abeta1-40-activated apoptotic pathway in cultured cortical neurons. 36th Annual Meeting of Society for Neuroscience, Atlanta, Georgia, 2006. Online Society for Neuroscience Meeting Planner Program No. 168.5, 2006.
Zhang HX and Wang XL. Effects of galantamine on cloned Kv2.1 and Kv1.5 potassium channels. 8th Annual Meeting of National Society for Biochemical Pharmacology Society in China, Qingdao, China, 2003. Chinese Pharmacologist, 20(3): 71, 2003.
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