Harley Takatsuna Kurata

Department of Cell Biology and Physiology
Washington University School of Medicine
660 S. Euclid Ave., Campus Box 8228
St. Louis, MO

Telephone: Work: 314-362-6629
Mobile: 314-541-7266
Fax: 314-362-7463
e-mail: harley.kurata at cellbiology dot wustl dot edu

EDUCATION

Oct. 2004 University of British Columbia, Vancouver, Canada
Ph.D., Physiology
Project Title: Structural determinants of Kv1.5 inactivation
Supervisor: Dr. David Fedida

May 1999 University of British Columbia, Vancouver, Canada
B.Sc.(Hons.), Physiology
Honors: Governor General’s Silver Medal

AWARDS:

2004-2007 Canadian Institutes of Health Research Post-Doctoral Fellowship
2004 Pederson Prize for Graduate Student Research
2001-2004 Canadian Institutes of Health Research/Heart and Stroke Foundation of Canada
Pre-doctoral Award
2001-2004 Micheal Smith Foundation for Health Research Pre-doctoral Award
1999-2001 Li Tze Fong University Graduate Fellowship
1999 Governor General’s Silver Medal
1999 Edgar C. Black Memorial Prize in Physiology
1999 Kurt Henze Memorial Prize
1996, 1998 J. Fred Muir Memorial Scholarship in Science
1997 Joseph P Ruffel Scholarship in Science
1996 Joel Harold Marcoe Memorial Scholarship
1995-1999 University of British Columbia National Scholar
1995-1999 Dean’s Honour List
1997-1999 University of British Columbia Science Scholar
1995 Governor General’s Bronze Medal
1995 Alberta Government Rutherford Scholar

TEACHING AND SUPERVISORY EXPERIENCE:

1999-2003 University of British Columbia, Vancouver, Canada
Teaching Assistant: Instructed weekly meetings of Physiology 430 (4th year Physiology laboratory course).

2001-2002 University of British Columbia, Vancouver, Canada
Supervised the undergraduate research project of Gordon Soon (currently 3rd year medical student at UBC).

2003-2004 University of British Columbia, Vancouver, Canada
Supervised the undergraduate research project of Monica Leung (currently a Ph.D. student at NYU).

PROFESSIONAL SERVICE:

2002-2004 University of British Columbia, Vancouver, Canada
Graduate Student Society Councillor, Physiology Dept. Representative.

1999-2003 University of British Columbia, Vancouver, Canada
Teaching Assistants Union Representative, Physiology Dept. Representative

PEER-REVIEWED PUBLICATIONS:

Kurata, H.T., Marton, L.J., and C.G. Nichols. 2005. The Polyamine Binding Site in Inward Rectifier K+ Channels. Submitted.

Kurata, H.T., and D. Fedida. 2005. A Structural Interpretation of Kv Channel Inactivation. Prog. Mol. Biol. Biophys. In Press.

Kurata, H.T. Doerksen, K.W., Eldstrom J.R., Rezazadeh, S., and D. Fedida. 2005. Separation of P/C- and U-type inactivation pathways in Kv1.5 potassium channels. J. Physiol. 568(1):31-46. [Abstract]

Kurata, H.T., Phillips, L.R., Rose, T., Loussouarn, G., Herlitze, S., Fritzenschaft, H., Enkvetchakul, D., Nichols, C.G., and T. Baukrowitz. 2004. Molecular Basis of Inward-rectification: Polyamine interaction sites located by combined channel and ligand mutagenesis. J. Gen. Physiol. 124(5):541-554. [Abstract]

Kurata, H.T., Wang, Z., and D. Fedida. 2004. Inactivation peptide binding to C-type inactivated K+ channels. J. Gen. Physiol. 123(5):505-520. [Abstract]

Zhang, S., Kurata, H.T., Kehl, S.J., and D. Fedida. 2003. Rapid induction of P/C-type inactivation is the mechanism for acid-induced K+ current inhibition. J. Gen. Physiol. 121(3):215-225. [Abstract]

Kurata, H.T., Soon, G.S., Eldstrom, J.R., Lu, G.W.K., Steele, D.F., and D. Fedida. 2002. Amino-terminal determinants of U-type inactivation in voltage-gated K+ channels. J. Biol. Chem. 277(32):29045-29053. [Abstract]

Kurata, H.T., Soon, G.S., and D. Fedida. 2001. Altered state dependence of C-type inactivation in the long and short forms of human Kv1.5. J. Gen. Physiol. 118(3):315-332. [Abstract]

BOOK CHAPTERS:

Kurata, H.T., Nichols, C.G. 2005 Inward-Rectification of Potassium Channels: Towards a Molecular Picture In Polyamine Cell Signaling: Phyiology, Pharmacology, and Cancer Research Edited By Wang, J.Y., Casero, R.A. Humana Press, NJ, USA.

ABSTRACTS:

Kurata, H.T., Phillips, L.R., Rose, T., Loussouarn, G., Herlitze, S., Fritzenschaft, H., Enkvetchakul, D., Nichols, C.G., and T. Baukrowitz. 2005. Molecular Basis of Inward-rectification: Localizing Polyamine Binding Sites in Kir Channels. 2005 Biophysical Society Meeting, Long Beach, USA. Biophys. J. 88(1): 283a.

Rezazadeh, S., Kurata, H.T., Khurana, A., Fedida, D. 2005. T1 Domain Modulation of Kv Channel Activation Through Interactions with Transmembrane Domains. 2005 Biophysical Society Meeting, Long Beach, USA. Biophys. J. 88(1): 460a.

Kurata, H.T., Phillips L.R., Enkvetchakul, D., Baukrowitz, T., Nichols, C.G. 2004. Molecular Basis of Inward Rectification: Localizing Polyamine Binding Sites in Kir Channels. Gordon Conference on Ion Channels, Tilton, New Hampshire, USA.

Eldstrom, J.R., Kurata, H.T., Steele, D.F., and D. Fedida. 2003. Exploring ion channel retention signals in the amino-terminus of hKv1.5. 2003 American Society for Cell Biology Meeting, San Francisco, USA. Mol. Biol. Cell. 14(Suppl.):228a.

Wang, Z., Kurata, H.T., Choi, W.S., Accili, E.A., and D. Fedida. 2004. Distinct effects of N-terminal domains on the C-type inactivated pore of the Kv1.4 channel. 2004 Biophysical Society Meeting, Baltimore, USA. Biophys. J. 86(1): 534a

Kurata, H.T., Wang, Z., and D. Fedida. 2004. Inactivation peptide binding to C-type inactivated K+ channels. 2004 Biophysical Society Meeting, Baltimore, USA. Biophys. J. 86(1):539a

Kurata, H.T., and D. Fedida. 2003. Separable effects of the Kv1 T1 domain on channel activation and deactivation. 2003 Biophysical Society Meeting, San Antonio, USA. Biophys. J. 83(2): 74a.

Kurata, H.T., Soon, G.S., and D. Fedida. 2002. Amino-terminal determinants of U-type inactivation in voltage-gated K+ channels. Joint Meeting of The Physiological Society and The German Physiological Society, Tuebingen, Germany. Pflugers Arch. 443: S277

Kurata, H.T., Soon, G.S., and D. Fedida 2002. T1 domain modulation of slow inactivation in Kv1.5 is subfamily specific. 2002 Biophysical Society Meeting, San Francisco, USA. Biophys J. 82(1): 299a.

MEMBERSHIPS:

2001-present Student member, The Biophysical Society