Decha Enkvetchakul

Address:
Department of Cell Biology and Physiology
Washington University School of Medicine
Box 8228
660 South Euclid Avenue
St. Louis, MO 63110, U.S.A.

Telephone: 314-362-6629
FAX No.: 314-362-7463
E-mail: denkvetchakul at cellbiology dot wustl dot edu

Education

1989 B.A., Biology. Washington University, Saint Louis, MO. 1993 M.D. University of Missouri-Columbia School of Medicine, Columbia, MO.

Employment:

1993-1996 Residency, Internal Medicine. Barnes Hospital, Saint Louis, MO
1996-1997 House Physician. Barnes-West County Hospital, Saint Louis, MO
1997-2001 Fellowship, Nephrology. Barnes-Jewish Hospital, Saint Louis, MO
2001-present Instructor. Renal Division, and Department of Cell Biology and Physiology
Washington University Medical School, Saint Louis, MO

Research

6/1997-6/2001 Nephrology Fellowship
Mechanism of ATP inhibition in KATP channels
Mentor: Colin G. Nichols, Professor
Washington University, Saint Louis, MO

6/2001-Present Mentored Clinical Scientist Development Award
NIH/NIDDK 5 K08 DK060086-02 (PI: Decha Enkvetchakul)
Mechanisms and kinetics of gating in K channels
Mentor: Colin G. Nichols, Professor
Washington University, Saint Louis, MO

Certifications

Board certified in Internal Medicine
Board certified in Nephrology
Fellow American Society of Nephrology

Publications

1. Enkvetchakul D, Jeliazkova I, Nichols CG. Direct modulation of K channel gating by membrane PIP2. J Biol Chem. 2005; 280(43):35785-8. Epub 2005 Sep 6. [Abstract]

2. Makary SM, Claydon TW, Enkvetchakul D, Nichols CG, Boyett MR. A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels. J Physiol 2005;568(Pt 3):749-66. Epub 2005 Aug 18 [Abstract]

3. Masia R, Enkvetchakul D, Nichols CG. Differential nucleotide regulation of KATP channels by SUR1 and SUR2A. J Mol Cell Card 2005; 39, 491-501. [Abstract]

4. Enkvetchakul D, Bhattacharyya J, Jeliazkova I, Groesbeck DK, Cukras CA, Nichols CG. Functional characterization of a prokaryotic Kir channel. Journal of Biological Chemistry 2004; 279(45):47076-80. [Abstract]

5. Flagg TP, Charpentier F, Manning-Fox J, Remedi MS, Enkvetchakul D, Lopatin A, Koster J and Nichols CG et al. Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels. American Journal of Physiology - Heart & Circulatory Physiology 2004; 286(4):1361-9. [Abstract]

6. Hardinger KL, Schnitzler MA, Koch MJ, Enkvetchakul D, Desai N, Jendrisak M, Lowell JA, Miller B, Shenoy S and Brennan DC. Cyclosporine minimization and cost reduction in renal transplant recipients receiving a C2-monitored, cyclosporine-based quadruple immunosuppressive regimen. Transplantation 2004; 78(8):1198-203. [Abstract]

7. Hardinger KL, Schnitzler MA, Miller B, Lowell JA, Shenoy S, Koch MJ, Enkvetchakul D, Ceriotti C and Brennan DC. Five-year follow up of thymoglobulin versus ATGAM induction in adult renal transplantation. Transplantation 2004; 78(1):136-41. [Abstract]

8. Kurata HT, Phillips LR, Rose T, Loussouarn G, Herlitze S, Fritzenschaft H, Enkvetchakul D, Nichols CG and Baukrowitz T. Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis. J Gen Physiol 2004; 124(5):541-54. [Abstract]

9. Dibb KM, Rose T, Makary SY, Claydon TW, Enkvetchakul D, Leach R, Nichols CG and Boyett MR. Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel. Journal of Biological Chemistry 2003; 278(49):49537-48. [Abstract]

10. Enkvetchakul D, Nichols CG. Gating mechanism of KATP channels: function fits form. Journal of General Physiology 2003; 122(5):471-80. [Abstract]

11. Enkvetchakul D, Ebihara L, Nichols CG. Polyamine flux in Xenopus oocytes through hemi-gap junctional channels. Journal of Physiology 2003; 553(Pt 1):95-100. [Abstract]

12. Phillips LR, Enkvetchakul D, Nichols CG. Gating dependence of inner pore access in inward rectifier K(+) channels. Neuron 2003; 37(6):953-62. [Abstract]

13. Enkvetchakul D, Loussouarn G, Makhina E, Nichols CG. ATP interaction with the open state of the K(ATP) channel. Biophysical Journal 2001; 80(2):719-28. [Abstract]

14. Koster JC, Knopp A, Flagg TP, Markova KP, Sha Q, Enkvetchakul D, Betsuyaku T, Yamada KA and Nichols CG. Tolerance for ATP-insensitive K(ATP) channels in transgenic mice. Circulation Research 2001; 89(11):1022-9. [Abstract]
15. Enkvetchakul D, Loussouarn G, Makhina E, Shyng SL, Nichols CG. The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding. Biophysical Journal 2000; 78(5):2334-48. [Abstract]
16. Windus D, Enkvetchakul D. Fluids, Electrolytes, and Acid-Base Disturbances. In: Murphy TP, Benenati JF, Kaufman JA, editors. Patient Care in Interventional Radiology. Fairfax, VA: The Society of Cardiovascular and Interventional Radiology, 1999: 205-216.