Anlong Li, M.D., Ph.D.

Department of Cell Biology and Physiology
Washington University School of Medicine
660 South Euclid Avenue
St. Louis, MO 63110, U.S.A.

Telephone: 314-362-6629
FAX No.: 314-362-7463

EDUCATION

1987-1992 Department of Medicine, Medical School of Zhengzhou University. Zhengzou, China.

Major in Clinical Medicine, M.D. awarded in 1992

1997-2002 Depatment of Pharmacology, Peking Union Medical College. Beijing China.

Major in Cardiovascular Pharmacology, Ph.D. awarded in 2002

PROFESSIONAL APOINTMENTS

1992-1997 Residency, Dept. of Cardiology, Hospital of Xinchuan County, Xinchuan, China.

2003-2006 Postdoctoral Fellow, Dept. of Physiology, University of Tennessee Health Science Center, Memphis, TN.

2007-2008 Research Fellow, Dept. of Anesthesiology & Critical Care Medicine, John Hopkins University of Medicine, Baltimore, MD.

2008-2009 Research Fellow, Dept. of Pulmonary & Critical Care Medicine, John Hopkins University of Medicine, Baltimore, MD.

2009-Present Staff Scientist, Dept. of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO.

RESEARCH INTERESTS

My major focus is to investigate the functional significance of arterial smooth muscle cell plasma membrane ion channels (mainly in BK & KATP channels) and calcium signals in regulating arterial smooth muscle cell contractility.  Techniques include patch clamp electrophysiology, rapid confocal calcium imaging, conventional calcium imaging, and diameter measurement of pressurized arteries, use of gene knockout & transgenic animal models, and molecular biology. 

SELECTED PUBLICATIONS

1. Li A, Xi Q, Umstot ES, Bellner L, Schwartzman ML Jaggar JH, Leffler CW. Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle cell KCa channels. Circ. Res. 2008 Feb 1;102(2):234-41

2. Li A, Adebiyi A, Leffler CW, Jaggar JH. KCa Channel Insensitivity to Ca2+ Sparks Underlies Fractional Uncoupling in Newborn Cerebral Artery Smooth Muscle Cells. Am. J. Physiol. 2006 Sep; 291(3): H1118-H1125.

3. Jaggar JH, Li A, Parfenova H, Liu J, Umstot ES, Dopico AM, Leffler CW. Heme Is A Carbon Monoxide Receptor For Large-Conductance Ca2+-Activated K+ Channels. Circ. Res. 2005 Oct 14; 97(8):805-12.

4. Li A, Liu ZW, Zhu LX, Zhang DC, Ye YX. Activation of Ca2+-Activated K+ Channels By Oxyphenamone In Rabbit Mesenteric Vascular Smooth Muscle Cells. Acta Pharmaceutica Sinica 2004 Feb; 39(2):101-4.

5. Li A, Ye YX. Study on Vasorelaxations of Oxyphenamone and Its Mechanism. Acta Pharmaceutica Sinica. 2002.37(1). 10-13.

6. Li A, Ye YX. Study on Vasorelaxations of Oxyphenamone and Its Mechanism. Chinese Cardiovascular Pharmacological Communication. 2002.3: 35.

PROFESSIONAL MEMBERSHIPS

Biophysical Society (2004 - present); American Physiological Society (2007-present)